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On the preparation of acyl cyanides from aldehydes
Author(s) -
Härle Helmut,
Jochims Johannes C.
Publication year - 1986
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19861190425
Subject(s) - chemistry , trimethylsilyl cyanide , aldehyde , organic chemistry , scope (computer science) , cyanide , trimethylsilyl , medicinal chemistry , catalysis , computer science , programming language
The O ‐silylated cyanohydrins 3 prepared from the aldehydes 1 with trimethylsilyl cyanide are oxidized photochemically or thermally with N ‐bromosuccinimide to afford the acyl cyanides 4a–n . Scope and limitations of the procedure are discussed.