Premium
Synthese von 2‐Methyl‐4 H ‐1,3‐benzoxazin‐4‐onen und analogen Verbindungen
Author(s) -
Stegmann Hartmut B.,
Klotz Dieter,
Weiß Joachim E.
Publication year - 1985
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19851181136
Subject(s) - chemistry , intramolecular force , wittig reaction , medicinal chemistry , condensation , stereochemistry , organic chemistry , physics , thermodynamics
Synthesis of 2‐Methyl‐4 H ‐1,3‐benzoxazin‐4‐ones and Related Compounds 4 H ‐1,3‐benzoxazin‐4‐ones 2 are smoothly prepared via (acylimino)phosphoranes 1 by intramolecular condensation analogous to a Wittig reaction. Tert. phosphanes are used for the preparation of the (acylimino)phosphoranes 1 which are converted into the corresponding benzoxazines and tert. phosphane oxides, e.g. 2‐methyl‐4 H ‐1,3‐benzoxazin‐4‐one ( 2a ) which, in spite of some attempts, has not been obtained before.