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Konfiguration der Praziquantel‐Enantiomeren
Author(s) -
Blaschke Gottfried,
Walther Bernd
Publication year - 1985
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19851181133
Subject(s) - chemistry , praziquantel , enantiomer , stereochemistry , methanol , organic chemistry , schistosomiasis , zoology , helminths , biology
Configuration of the Praziquantel Enantiomers The levorotatory (methanol) enantiomer of the anthelminthic agent praziquantel ( rac ‐ 1 ) is R ‐, the dextrorotatory S ‐configurated. This assignment is based upon CD‐spectra of both enantiomers and additionally confirmed by conversion of (+)‐ and (−)‐ 2 to the pyrazinoisoquinolines 3 of known configuration.

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