Premium
Eine einfache Synthese primärer Amine über ihre N,N ‐Bis(trimethylsilyl)‐Derivate
Author(s) -
Bestmann Hans Jürgen,
Wölfel Gerhard
Publication year - 1984
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19841170338
Subject(s) - chemistry , trimethylsilyl , amine gas treating , primary (astronomy) , amide , halogen , aqueous solution , medicinal chemistry , organic chemistry , physics , alkyl , astronomy
A Simple Synthesis of Primary Amines via their N,N ‐Bis(trimethylsilyl) Derivatives Primary halogen compounds 1 or the corresponding tosylates react with sodium bis(trimethylsilyl)amide ( 2 ) in hexamethyldisilazine to form N,N ‐bis(trimethylsilyl)amines 3 , which are converted into the amine hydrochlorides 5 by treatment with aqueous HCl.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom