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Synthesis and Structure of as ‐Triazinoquinazolines, II
Author(s) -
Badawy Mohamed A.,
AbdelHady Sayed A. L.,
Eid Mohga M.,
Ibrahim Yehia A.
Publication year - 1984
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19841170323
Subject(s) - chemistry , anthranilic acid , benzonitrile , yield (engineering) , quinazoline , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
4‐Amino‐3‐(methylthio)‐6‐R‐1,2,4‐triazin‐5(4 H )‐ones 6 – 10 react with anthranilic acid to yield the 1‐amino‐3‐R‐2 H ‐ as ‐triazino[3,2‐ b ]quinazoline‐2,6(1 H )‐diones 17 – 21 rather than the expected as ‐triazino[3,4‐ b ][1,3,4]benzotriazepines 12 – 16 . Compounds 17 – 21 were deaminated into compounds 22 – 26 . Heating of the N ‐benzylidene derivatives of 6 – 10 (27 – 31) with anthranilic acid also led to the formation of 22 – 26 with extrusion of benzonitrile.