Nucleosides, 38 1)   The Ribonucleosides of Allopurinol | Zendy

Lichtenthaler Frieder W. | Zendy; Cuny Eckehard | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Nucleosides, 38 1) The Ribonucleosides of Allopurinol

Author(s) -

Lichtenthaler Frieder W.,

Cuny Eckehard

Publication year - 1981

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19811140505

Subject(s) - chemistry , allopurinol , trifluoromethanesulfonate , trimethylsilyl , xanthine oxidase , stereochemistry , catalysis , trimethylsilyl trifluoromethanesulfonate , medicinal chemistry , glycosylation , organic chemistry , enzyme , biochemistry , medicine , pathology

Of the various conceivable ribonucleosides of allopurinol, the N ‐1‐, N ‐2‐, and N ‐5‐isomers (9c‐11c) as well as the 1, 5‐and 2,5‐bis‐ribosylated derivatives 6c and 7c have been prepared via stannic chloride‐induced glycosylation of bis (trimethylsilyl)allopurinol 4 with acylated ribofuranoses (5) . Trimethylsilyl triflate as catalyst in addition produced the O 4 ‐ribosylated isomer 8a . – The structures of the products were secured from UV, 1 H, and 13 C NMR data. –Their xanthine oxidase inhibitory activity was evaluated.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research