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Asymmetrische Synthesen, VII. Herstellung optisch aktiver Aminonitrile
Author(s) -
Weinges Klaus,
Blackholm Heinz
Publication year - 1980
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19801130926
Subject(s) - chemistry , optically active , epimer , chirality (physics) , absolute configuration , stereochemistry , medicinal chemistry , organic chemistry , chiral symmetry breaking , symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model
Asymmetric Syntheses, VII 1) . Synthesis of Optically Active Aminonitriles The optically active crystalline aminonitriles 3a – n and 4o are obtained from ketones 1a – o , (4 S ,5 S )‐(+)‐5‐amino‐2,2‐dimethyl‐4‐phenyl‐l,3‐dioxane ( 2 ), and hydrocyanic acid. The absolute configuration of the newly formed centers of chirality (* in 3 and 4 ), and the epimer equilibria (table 1) in solution are determined by 1 H NMR spectroscopy.
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