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Chromatographische Racemattrennungen, X. Racemattrennung des Thalidomids und anderer Glutarimid‐Derivate
Author(s) -
Blaschke Gottfried,
Kraft HorstPeter,
Markgraf Hildegunde
Publication year - 1980
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19801130626
Subject(s) - chemistry , enantiomer , polyamide , chromatography , stereochemistry , organic chemistry
Chromatographie Resolutions of Racemates, X. Optical Resolutions of Thalidomide and Other Glutarimide Derivatives Racem . thalidomide ( 1a ) is resolved completely by chromatography on the chiral polyamide 2e in an analytical as well as preparative scale. The glutarimides 1b – d are partially resolved. Both enantiomers of 1b and one enantiomer of 1d were isolated by recycling chromatography.