Notizen Reaktionsfähigkeit von Aporphin‐Alkaloiden gegenüber Formaldehyd | Zendy

Mollov Nikola | Zendy; Philipov Stefan | Zendy

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Notizen Reaktionsfähigkeit von Aporphin‐Alkaloiden gegenüber Formaldehyd

Author(s) -

Mollov Nikola,

Philipov Stefan

Publication year - 1979

Publication title -

chemische berichte

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 0009-2940

DOI - 10.1002/cber.19791121122

Subject(s) - chemistry , formaldehyde , hydrobromic acid , enamine , acetic acid , hydrolysis , organic chemistry , reactivity (psychology) , polymer chemistry , medicinal chemistry , catalysis , medicine , alternative medicine , pathology

Reactivity of Aporphine Alkaloids against Formaldehyde Glaucine ( 1 ) reacts with formaldehyde in neutral medium to form 4 . As an intermediate 5 is obtained which has a weak enamine chracter against formaldehyde. Bracteoline ( 2 ) can be obtained after hydrobromic acid/acetic acid hydrolysis of 1 . Treatment of 2 with formaldehyde in alkaline media leads to 3 , which on heating near the melting point (about 150°C) is converted into 6 . This is a new route for the synthesis of thalphenine‐type alkaloids.

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