Premium
Notizen Reaktionsfähigkeit von Aporphin‐Alkaloiden gegenüber Formaldehyd
Author(s) -
Mollov Nikola,
Philipov Stefan
Publication year - 1979
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19791121122
Subject(s) - chemistry , formaldehyde , hydrobromic acid , enamine , acetic acid , hydrolysis , organic chemistry , reactivity (psychology) , polymer chemistry , medicinal chemistry , catalysis , medicine , alternative medicine , pathology
Reactivity of Aporphine Alkaloids against Formaldehyde Glaucine ( 1 ) reacts with formaldehyde in neutral medium to form 4 . As an intermediate 5 is obtained which has a weak enamine chracter against formaldehyde. Bracteoline ( 2 ) can be obtained after hydrobromic acid/acetic acid hydrolysis of 1 . Treatment of 2 with formaldehyde in alkaline media leads to 3 , which on heating near the melting point (about 150°C) is converted into 6 . This is a new route for the synthesis of thalphenine‐type alkaloids.