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Eine neue Synthese der 5‐Butyl‐2‐pyridincarbonsäure (Fusarsäure) über die „Emmert‐Reaktion”︁
Author(s) -
Tschesche Rudolf,
Führer Wolfgang
Publication year - 1978
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19781111024
Subject(s) - chemistry , medicinal chemistry , yield (engineering) , dehydration , metallurgy , biochemistry , materials science
A New Synthesis of 5‐Butyl‐2‐pyridinecarboxylic Acid (Fusaric Acid) Using the „Emmert Reaction” 3‐Butylpyridine ( 1 ) reacted with aliphatic ketones in the presence of amalgamated magnesium to yield the 5‐substituted 2‐pyridinemethanols 2a , b . Dehydration to 3a , b , followed by permanganate oxidation to 4 , and reaction with hypohalite gave 5‐butyl‐2‐pyridinecarboxylic acid ( 5 ).
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