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14β‐Konfigurierte Δ 8 ‐Ergosten‐Derivate
Author(s) -
Brunke ErnstJoachim
Publication year - 1978
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19781110834
Subject(s) - chemistry , methanol , derivative (finance) , medicinal chemistry , stereochemistry , organic chemistry , economics , financial economics
14β‐Configurated Δ 8 ‐Ergostene Derivatives The 6‐oxo‐Δ 7 ‐steroid 1 undergoes deconjugation by treatment with NaOH (methanol, reflux) to give a mixture of the known Δ 8(14) ‐isomer 2 and the new 14β‐Δ 8(9) ‐isomer 3 (4:1); 3 was mainly formed by higher temperature (130°C: 80% 3 ). Huang‐Minlon reduction of 1 yields the stable 14β‐Δ 8(9) ‐ergostene derivative 5 .
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