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Untersuchungen in der Isochroman‐ und Isothiochroman‐Reihe, XX. Über Derivate des 1,1′‐Methylenbis(isothiochromans)
Author(s) -
Böhme Horst,
Binder Elke,
Matusch Rudolf
Publication year - 1977
Publication title -
chemische berichte
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 0009-2940
DOI - 10.1002/cber.19771100930
Subject(s) - chemistry , diiodomethane , diastereomer , carbanion , saponification , medicinal chemistry , organic chemistry , surface energy
Investigations in the Isochromane and Isothiochromane Series, XX. Derivatives of 1,1′‐Methylenebis(isothiochromane) Isothiochromane‐1‐carbonitrile ( 1 ) and isothiochromane‐2,2‐dioxide ( 2 ) react via the carbanions 3 and 4 with diiodomethane to give mixtures of the racemic and the meso form of 1,1‐methylenebis‐(isothiochromanes) 5A/5B and 8A/8B , respectively. The separation of the diastereomers is achieved by fractionating crystallization combined with preparative layer‐chromatography.