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Front Cover: Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone (Chem. Biodiversity 8/2022)
Author(s) -
Zou Jiabin,
Wu Jialing,
Ding Lijian,
Wang Weiyi,
Liu Yinghui,
Feng Yunping,
Lai Qiliang,
Lin Wenhan,
Wang Tingting,
He Shan
Publication year - 2022
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202200724
Subject(s) - sponge , daidzein , coral , front cover , coral reef , chemistry , ec50 , fungus , botany , ecology , biology , genistein , cover (algebra) , biochemistry , mechanical engineering , engineering , in vitro , endocrinology
Front Cover . Mesophotic coral ecosystems (MCEs; moderately lit coral ecosystems from 30–150 m depth) have been known to exist since the 19 th century, but over 70 % of all studies on MCEs have been published during the last decade. Compared to their shallow counterparts, although MCEs are estimated to represent about 80 % of coral reef habitat globally, relatively little research has been performed on them. Our continuous program was devoted to the search for structurally unique and biologically active secondary metabolites from sponge‐associated fungi in MCEs for their broad spectrum of metabolism. Among these, the fungus Penicillium sp. NBUF154 was cultivated from a 60 m Crella sponge and chemically investigated. Two new meroterpenes here named guignardones Y and Z ( 1 and 2 ), two known guignardones A and H ( 3 and 4 ), as well as two known isoflavones gyorgy‐isoflavone ( 5 ) and daidzein ( 6 ), blumenol A ( 7 ) and guignardianone A ( 8 ) were discovered from its fermentation broth. Guignardone Y ( 1 ) exhibited potent antiviral activity towards EV71 with the EC 50 value of 1.25 μM in their research article at 10.1002/cbdv.202200475.