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Front Cover: New Cytotoxic Secondary Metabolites from Two Deep‐Sea‐Derived Fungi and the Co‐Culture Impact on the Secondary Metabolic Patterns (Chem. Biodiversity 4/2022)
Author(s) -
Li Xuanyi,
Ge Yichao,
Ma Yihan,
Wang Shoubao,
Li Sihui,
Yin Qizhao,
Liu Xiaowan,
Wie Jihua,
Wu Xiaodan,
Wu Bin
Publication year - 2022
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202200220
Subject(s) - front cover , chemistry , penicillium , strain (injury) , molecule , stereochemistry , acetylation , secondary metabolite , cover (algebra) , biochemistry , organic chemistry , food science , biology , gene , anatomy , mechanical engineering , engineering
Front Cover . Chemical profiles and cross talk molecules of two co‐existing deep‐sea‐derived Penicillium fungal strains were investigated. Totally, three new compounds and 23 known compounds were identified from the two strains, and five of them showed potent antiproliferative activity. Co‐culture experiments were conducted by a device that allows only small molecule to communicate to find cross‐talk molecules. Extensive HPLC‐MS 2 experiments were applied to investigate the disturbance of the chemical profiles within the synthetic Penicillium ‐ Penicillium community. The fungal strain LXY140‐R was found to accumulate mono or multiple‐acetylation derivatives of DON sesquiterpenes as responsible molecules by the disturbance of the metabolites produced by the LXY140‐3 strain as reported by X. Li et al . in their research article at 10.1002/cbdv.202200055.