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Biochemical Characterization and Antimicrobial Activity against Some Human or Phyto‐Pathogens of New Diazonium Heterocyclic Metal Complexes
Author(s) -
ElAttar Mohamed S.,
Elshafie Hazem S.,
Sadeek Sadeek A.,
ElFarargy Ahmed F.,
ElDesoky Sameh I.,
ElShwiniy Walaa H.,
Camele Ippolito
Publication year - 2022
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100785
Subject(s) - chemistry , denticity , metal , ligand (biochemistry) , chelation , nuclear chemistry , anthranilic acid , medicinal chemistry , stereochemistry , inorganic chemistry , organic chemistry , biochemistry , receptor
String of vanadium (IV), zirconium (IV), palladium (II), platinum (IV) and uranium (VI) chelates of 2‐cyano‐2‐[(2‐nitrophenyl)hydrazono]thioacetamide (Cnphta) were prepared and characterized by physicochemical, spectroscopic and thermal analyses. The formulae of the isolated solid complexes were assigned as [VO(Cnphta) 2 (H 2 O)]SO 4 ⋅ 5H 2 O ( 1 ), [ZrO(Cnphta) 2 (H 2 O)]Cl 2 ⋅ 4H 2 O ( 2 ), [Pd(Cnphta) 2 ]Cl 2 ( 3 ), [Pt(Cnphta) 2 Cl 2 ]Cl 2 ( 4 ) and [UO 2 (Cnphta) 2 ](NO 3 ) 2 ⋅ 5H 2 O ( 5 ). The infrared assignments clearly showed that Cnphta ligand coordinated as a bidentate feature through the hydrazono nitrogen and the thioacetamide nitrogen for V(IV), Zr(IV) and U(VI) but displayed different behavior for Pd(II) and Pt(IV). Results of the molar conductivities measurements showed that the metal complexes were electrolytes in contrast with Cnphta ligand. The interpretation, mathematical analysis and evaluation of kinetic parameters were also carried out. In addition, the studied ligand and its new chelates were tested for their antimicrobial activity against some human or phytopathogenic microorganisms. The new metal complexes explicated promising antibacterial activity against all tested bacteria especially Staphylococcus aureus and Bacillus subtilis . Regarding the antifungal activity, all metal complexes were able to inhibit the mycelium growth of both tested pathogenic fungi. In particular Zr(IV) and Pt(IV) complexes showed the highest significant fungicidal effect against A. fumigatus similar to positive control.