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Front Cover: Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models (Chem. Biodiversity 8/2021)
Author(s) -
Kowalczyk Tomasz,
Sitarek Przemysław,
Toma Monika,
Rijo Patricia,
DomínguezMartín Eva,
Falcó Irene,
Sánchez Gloria,
Śliwiński Tomasz
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100535
Subject(s) - betulinic acid , chemistry , triterpene , endodermis , botany , biological activity , agrobacterium , transgene , traditional medicine , biochemistry , biology , in vitro , gene , medicine , genetics , alternative medicine , pathology
Front Cover . Betulinic acid is a pentacyclic triterpene with distinctive pharmacological activities. As reported by Kowalczyk et al . in their full paper at 10.1002/cbdv.202100455 there are differences in the content of betulinic acid and selected anthraquinones in transgenic Senna obtusifolia hairy roots with overexpression of the PgSS1 gene and in transformed hairy roots without this genetic construct. Both hairy root lines grew in 10 L sprinkle bioreactor. The extracts obtained from this plant material were used for biological tests showing a cytotoxic and antiproliferative effect on U‐87MG glioblastoma cells and altering the level of apoptotic proteins (Bax, p53, Puma and Noxa). Antimicrobial and antiviral properties were also demonstrated for both tested extracts, with a stronger effect of transgenic hairy root extract.