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Biochemical Characterization, Phytotoxic Effect and Antimicrobial Activity against Some Phytopathogens of New Gemifloxacin Schiff Base Metal Complexes
Author(s) -
Mohamed Amira A.,
Elshafie Hazem S.,
Sadeek Sadeek A.,
Camele Ippolito
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100365
Subject(s) - chemistry , schiff base , metal , octahedral molecular geometry , octahedron , antimicrobial , metal ions in aqueous solution , chelation , phytotoxicity , carboxylate , stereochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , ion , botany , biology
String of Fe(III), Cu(II), Zn(II) and Zr(IV) complexes were synthesized with tetradentateamino Schiff base ligand derived by condensation of ethylene diamine with gemifloxacin. The novel Schiff base (4 E ,4′ E )‐4,4′‐(ethane‐1,2‐diyldiazanylylidene)bis{7‐[(4 Z )‐3‐(aminomethyl)‐4‐(methoxyimino)pyrrolidin‐1‐yl]‐1‐cyclopropyl‐6‐fluoro‐1,4‐dihydro‐1,8‐naphthyridine‐3‐carboxylic acid} (GMFX‐en) and its metal complexes were identified and confirmed by elemental analyses, FT‐IR, UV/VIS, 1 H‐NMR spectra, magnetic susceptibility, conductometric measurements and thermal analyses. The FT‐IR spectral data showed the chelation behavior of GMFX‐en toward the metal ions through oxygen of carboxylate group and nitrogen of azomethine group. In the light of all spectral data, these complexes presumably have octahedral geometry configurations. Thermal analysis specified that the decaying of the metal complexes exist in two or three steps with the final residue metal oxides. Antimicrobial activity of the new prepared metal complexes was screened against some common phytopathogens and their mode of action has been also discussed. The potential phytotoxic effectiveness of the new complexes was furthermore inspected on two commonly experimental plants. The complexes showed significant antimicrobial and phytotoxic effects against the majority of tested phytopathogens and the two tested plants, respectively. The potential antimicrobial activity of the complexes proved their possibility to be used successfully in agropharmacutical industry to control many serious phytopathogens. The phytotoxicity of the studied complexes also indicated their possibility as potential bio‐based herbicides alternatives to weed control in crop fields.