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Chemical Constituents from Staminate Flowers of Eucommia ulmoides Oliver and Their Anti‐Inflammation Activity in Vitro
Author(s) -
Li Rui,
Huang Tao,
Nie Lanlan,
Jia An,
Zhang Lei,
Yuan Ying,
Hong Yanlong,
Wang Jianying,
Hu Xiao
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100331
Subject(s) - eucommia ulmoides , chemistry , circular dichroism , time dependent density functional theory , glycoside , stereochemistry , in vitro , stamen , nitric oxide , density functional theory , biochemistry , computational chemistry , organic chemistry , botany , biology , medicine , pollen , alternative medicine , pathology , traditional chinese medicine
Three new monoterpenoids, named eucomylides A−C ( 1 – 3 ), along with six known compounds ( 4 – 9 ) were isolated from the staminate flowers of Eucommia ulmoides Oliver. The structures were elucidated by extensive analyses of spectroscopic methods, and their absolute configurations were established by time‐dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. All the compounds along with previously isolated components ( 10 – 14 ) were tested for their anti‐inflammatory effects. Two iridoid glycosides ( 11 and 12 ) and a flavonoid glycoside ( 14 ) showed potent suppressive effects on nitric oxide (NO) production in RAW 264.7 cells, with IC 50 values ranging from 17.11 to 22.26 μM.