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Synthesis and Anti‐Oomycete Activity of 1‐Sulfonyloxy/Acyloxydihydroeugenol Derivatives
Author(s) -
Chen Genqiang,
Zhu Lina,
He Jiaxuan,
Zhang Song,
Li Yuanhao,
Guo Xiaolong,
Sun Di,
Tian Yuee,
Liu Shengming,
Huang Xiaobo,
Che Zhiping
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100329
Subject(s) - oomycete , chemistry , fungicide , phytophthora capsici , sulfonyl , stereochemistry , alkyl , biochemistry , biology , organic chemistry , botany , food science , pepper , gene
Endeavor to discover biorational natural products‐based fungicides, two series (26) of novel 1‐sulfonyloxy/acyloxydihydroeugenol derivatives ( 3a – p and 5a – j ) were prepared and assessed for their fungicidal activity against P. capsici Leonian, in vitro . Results of fungicidal activity revealed that, among all compounds, especially compounds 3a , 5c , and 5e displayed the most potent anti‐oomycete activity against P. capsici with EC 50 values of 69.33, 68.81, and 67.77 mg/L, respectively. Overall, the anti‐oomycete activities of 1‐acyloxydihydroeugenol derivatives ( 5a – j ) were higher than that of 1‐sulfonyloxydihydroeugenol derivatives ( 3a – p ). It is proved that the introduction of the acyl group at hydroxy position of dihydroeugenol is more beneficial to improve its anti‐oomycete activity than that of the sulfonyl group. These preliminary results will pave the way for further modification of dihydroeugenol in the development of potential new fungicides.