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Green and Red Brazilian Propolis: Antimicrobial Potential and Anti‐Virulence against ATCC and Clinically Isolated Multidrug‐Resistant Bacteria
Author(s) -
Souza Silva Thayná,
Silva Júlia M. B.,
Braun Gláucia H.,
Mejia Jennyfer A. A.,
Ccapatinta Gari V. C.,
Santos Mário Ferreira Conceição,
Tanimoto Matheus H.,
Bastos Jairo K.,
Parreira Renato L. T.,
Orenha Renato P.,
Borges Alexandre,
Berretta Andresa A.,
Veneziani Rodrigo C. S.,
Martins Carlos H. G.,
Ambrósio Sérgio R.
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100307
Subject(s) - propolis , antimicrobial , chemistry , microbiology and biotechnology , multiple drug resistance , minimum inhibitory concentration , hemolysin , biofilm , bacteria , catalase , virulence , enzyme , biochemistry , biology , food science , antibiotics , genetics , gene
Brazilian green and red propolis stand out as commercial products for different medical applications. In this article, we report the antimicrobial activities of the hydroalcoholic extracts of green (EGP) and red (ERP) propolis, as well as guttiferone E plus xanthochymol (8) and oblongifolin B (9) from red propolis, against multidrug‐resistant bacteria (MDRB). We undertook the minimal inhibitory (MIC) and bactericidal (MBC) concentrations, inhibition of biofilm formation (MICB 50 ), catalase, coagulase, DNase, lipase, and hemolysin assays, along with molecular docking simulations. ERP was more effective by displaying MIC and MBC values <100 μg mL −1 . Compounds 8 and 9 displayed the lowest MIC values (0.98 to 31.25 μg mL −1 ) against all tested Gram‐positive MDRB. They also inhibited the biofilm formation of S. aureus (ATCC 43300 and clinical isolate) and S. epidermidis (ATCC 14990 and clinical isolate), with MICB 50 values between 1.56 and 6.25 μg mL −1 . The molecular docking results indicated that 8 and 9 might interact with the catalase's amino acids. Compounds 8 and 9 have great antimicrobial potential.