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Commiphoranes K−O, New Terpenoids from Resina Commiphora and Their Anti‐Inflammatory Activities
Author(s) -
Yang Xiaohua,
Wang Daiwei,
Yan Yongming,
Jiao Yabin,
Cheng YongXian,
Wang Feng
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100265
Subject(s) - terpenoid , chemistry , lipopolysaccharide , anti inflammatory , chemical constituents , stereochemistry , traditional medicine , pharmacology , chromatography , biology , immunology , medicine
Commiphorane K ( 1 ), a new dinorditerpenoid, commiphoranes L−N ( 2 – 4 ), three new germacrane‐type sesquiterpenoids, and commiphorane O ( 5 ), one new guaiane‐type sesquiterpenoid, were isolated from Resina Commiphora . Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X‐ray crystallography. Compounds 2 – 5 were evaluated for their anti‐inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)‐stimulated production of TNF‐ α in RAW264.7 cells in a dose‐dependent manner.