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Lignans from Lepidium meyenii and Their Anti‐Inflammatory Activities
Author(s) -
Zou YiYan,
Wang DaiWei,
Yan YongMing,
Cheng YongXian
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100231
Subject(s) - lignan , chemistry , rhizome , enantiomer , chiral column chromatography , stereochemistry , sesamin , lipopolysaccharide , anti inflammatory , traditional medicine , pharmacology , food science , biology , medicine , endocrinology
Meyeniines A–C ( 1 – 3 ), three new lignans, two known neolignans ( 4 – 5 ), and three known lignans ( 6 – 8 ) were isolated from the rhizomes of Lepidium meyenii . Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4 – 6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL‐6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose‐dependent manner.