Lignans from  Lepidium meyenii  and Their Anti‐Inflammatory Activities | Zendy

Zou YiYan | Zendy; Wang DaiWei | Zendy; Yan YongMing | Zendy; Cheng YongXian | Zendy

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Lignans from Lepidium meyenii and Their Anti‐Inflammatory Activities

Author(s) -

Zou YiYan,

Wang DaiWei,

Yan YongMing,

Cheng YongXian

Publication year - 2021

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.202100231

Subject(s) - lignan , chemistry , rhizome , enantiomer , chiral column chromatography , stereochemistry , sesamin , lipopolysaccharide , anti inflammatory , traditional medicine , pharmacology , food science , biology , medicine , endocrinology

Meyeniines A–C ( 1 – 3 ), three new lignans, two known neolignans ( 4 – 5 ), and three known lignans ( 6 – 8 ) were isolated from the rhizomes of Lepidium meyenii . Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4 – 6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL‐6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose‐dependent manner.

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