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Monalbidins A–E, Decalins with Potential Cytotoxic Activities from Marine Derived Fungus Monascus albidus BB3
Author(s) -
Guo Qi,
Lan WenJian,
Chen LiuPing,
Lam ChiKeung,
Feng GongKan,
Deng Rong,
Zhu XiaoFeng,
Li HouJin
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202100068
Subject(s) - chemistry , monascus , fungus , cytotoxicity , cancer cell lines , stereochemistry , food science , biochemistry , botany , fermentation , cancer cell , cancer , in vitro , biology , genetics
Abstract Five new decalins, monalbidins A–E ( 1 , 2 and 7–9 ), together with 16 known compounds ( 3 – 6 and 10–21 ), were isolated from the AcOEt extract of marine derived fungus Monascus albidus BB3 cultured in GPY medium. Among the known compounds, 1‐hydroxymonacolin L ( 11 ), dehydromonacolin J ( 15 ), 8‐ O ‐acetylmonacolin J ( 19 ) and O ‐acetylmonacolin K ( 21 ) were separated from natural sources for the first time. Their structures were determined by comprehensive analysis on the 1D and 2D NMR, HR‐ESI‐MS, UV and IR data, and their absolute configurations were assigned by experimental and calculated ECD data, and X‐ray single‐crystal diffraction analysis. Monalbidins C and D ( 7 and 8 ), monacolin K methyl ester ( 13 ), dehydromonacolin L ( 14 ), dehydromonacolin K ( 16 ), monacolin K ( 20 ) and O ‐acetylmonacolin K ( 21 ) showed moderate cytotoxicity against human cancer cell lines SUNE1, HepG2, QGY7701, HCT116 and MDA‐MB‐231.