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Eremophilane Sesquiterpenes and Benzene Derivatives from the Endophyte Microdiplodia sp. WGHS5
Author(s) -
Khan Babar,
Zhao Shuangshuang,
Wang Zhiyang,
Ye Yonghao,
Ahmed Rajput Nasir,
Yan Wei
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000949
Subject(s) - chemistry , endophyte , benzene , antimicrobial , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , cancer cell lines , terpenoid , sesquiterpene , organic chemistry , cancer cell , cancer , botany , biology , genetics
Three new eremophilane sesquiterpenes phomadecalins G−I ( 1 – 3 ) and two new benzene derivatives microdiplzenes A and B ( 12 and 13 ), together with nine known eremophilane sesquiterpenes ( 4 – 11 and 14 ) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR‐ESI‐MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC‐823).