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New Pyrano‐4 H ‐benzo[ g ]chromene‐5,10‐diones with Antiparasitic and Antioxidant Activities
Author(s) -
Al Nasr Ibrahim S.,
Jentzsch Jana,
Shaikh Amin,
Singh Shuveksh Priti,
Koko Waleed S.,
Khan Tariq A.,
Ahmed Khursheed,
Schobert Rainer,
Ersfeld Klaus,
Biersack Bernhard
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000839
Subject(s) - chemistry , amastigote , trypanosoma brucei , antiparasitic , antioxidant , toxoplasma gondii , leishmania , stereochemistry , derivative (finance) , antiparasitic agent , harmine , leishmania major , biochemistry , pharmacology , parasite hosting , biology , immunology , medicine , pathology , world wide web , computer science , economics , financial economics , antibody , gene
New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei , Leishmania major , and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single digit micromolar EC 50 values and against T. gondii with even sub‐micromolar values. The 3‐chloro‐4,5‐dimethoxyphenyl derivative showed an activity against amastigotes of Leishmania major parasites comparable to that of amphotericin B. In addition, antioxidant activities were observed for the bromophenyl derivatives, and their redox behavior was studied by cyclovoltammetry. Anti‐parasitic and antioxidative activities of the new naphthoquinone derivatives appear uncorrelated.