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Anti‐Inflammatory, Antioxidant and Enzyme Inhibition Activities in Correlation with Mycochemical Profile of Selected Indigenous Ganoderma spp. from Balkan Region (Serbia)
Author(s) -
Rašeta Milena,
Popović Mira,
Beara Ivana,
Šibul Filip,
Zengin Gokhan,
Krstić Sanja,
Karaman Maja
Publication year - 2021
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000828
Subject(s) - chemistry , abts , antioxidant , dpph , protocatechuic acid , anti inflammatory , hydroxybenzoic acid , enzyme , chloroform , food science , traditional medicine , biochemistry , chromatography , pharmacology , organic chemistry , biology , medicine
The aim of this research work was to study the bioactivity potentials (antioxidant, anti‐inflammatory, and enzyme inhibitory) of ethanol (EtOH), water (H 2 O) and chloroform (CHCl 3 ) extracts of G. applanatum , G. lucidum , G. pfeifferi and G. resinaceum as well as their mycochemical profile: the total content of phenolics (TP) and sugars (TS) and LC/MS/MS detection of phenolics. LC/MS/MS profile showed that p‐ hydroxybenzoic and protocatechuic acids were mostly found. The highest ABTS and DPPH activities were detected in polar G. applanatum extracts (159.84±0.59 mg TE/g d.w., IC 50 =0.85±0.30 μg/mL, respectively), while G. resinaceum CHCl 3 extract was the most potent in NO assay (IC 50 =41.21±0.18−81.89±0.81 μg/mL). The highest TP and TS were generally determined in G. applanatum EtOH extracts. Enzyme inhibitory effects were determined in H 2 O extracts. Generally, CHCl 3 extracts showed the most powerful anti‐inflammatory potential. These results suggest that analyzed species are a promising source of bioactive compounds and may be considered as candidates for new food supplements or drug formulations.