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Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects
Author(s) -
Wu XueWen,
Wang Qi,
Li Qing,
Cui YiMan,
Pu YuKun,
Shi QiangQiang,
Bi DeWen,
Zhang JingJing,
Zhang RuiHan,
Li XiaoLi,
Zhang XingJie,
Xiao WeiLie
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000798
Subject(s) - chemistry , inflammasome , stereochemistry , traditional medicine , chemical constituents , biochemistry , chromatography , medicine , receptor
Four new diterpenoids, rubellawus A–D ( 1 – 4 ), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella . Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti‐inflammatory activity and 14 α ‐hydroxyisopimaric acid and isopimaric acid showed significant NLRP3 inflammasome inhibitory activity with IC 50 values of 7.02 and 3.99 μM.