Premium
Cytotoxic Yohimbine‐Type Alkaloids from the Leaves of Rauvolfia vomitoria
Author(s) -
Zhan Guanqun,
Miao Rongkun,
Zhang Fuxin,
Wang Xingbin,
Zhang Xinxin,
Guo Zengjun
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000647
Subject(s) - yohimbine , chemistry , cytotoxicity , apocynaceae , stereochemistry , alkaloid , monoterpene , indole test , cell culture , in vitro , organic chemistry , botany , biochemistry , receptor , biology , antagonist , genetics
Two new yohimbine‐type monoterpene indole alkaloids, rauvines A and B, and six known derivatives were obtained from the leaves of R. vomitoria . The structures of rauvines A and B were determined by extensive spectroscopic analyses, 13 C‐NMR, and ECD calculations. This is the first time to determine the absolute configurations of yohimbine‐type N ‐oxides by quantum chemistry calculations ( 13 C‐NMR and ECD calculations). All the isolates were tested for their cytotoxicity against five human cancer cell lines. Rauvine B showed moderate cytotoxicity on human MCF‐7 breast, SWS80 colon, and A549 lung cancer cell lines with IC 50 values of 25.5, 22.6, and 26.0 μM, respectively.