Front Cover: New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment‐Derived Fungus Epicoccum nigrum SD‐388 (C&B 8/2020)

Front Cover . The extreme environment in the deep sea led to the presence of a characteristic thriving world of microbial diversity. With the development of sampling techniques, fungi derived from deep sea (> 1000 m) have attracted considerable attention on account of special biological diversity and prolific metabolisms. Epicoccum nigrum SD‐388 is a deep‐sea‐sediment‐derived fungus with characteristic metabolites of thiodiketopiperazine derivatives (TDKPs), which displays a variety of bioactivities. Systematical isolation of the culture extract resulted in the isolation of two new TDKPs, namely 7‐dehydroxyepicoccin H ( 1 ) and 7‐hydroxyeutypellazine F ( 2 ), along with seven known TDKP analogs. Significant inhibitory activities of these compounds against aquatic pathogens Vibrio vulnificus , V. alginolyticus , and Edwardsiella tarda were observed, as reported by Wang et al . in their full paper at 10.1002/cbdv.202000320.