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Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019
Author(s) -
Lu Silei,
Wang Jiangming,
Sheng Ruilong,
Fang Yiwen,
Guo Ruihua
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000562
Subject(s) - actinobacteria , organism , marine species , biology , computational biology , chemistry , ecology , gene , paleontology , biochemistry , 16s ribosomal rna
Marine organism‐associated actinobacteria represent a valuable resource for marine drugs due to their abundant secondary metabolites. The special environments in the ocean, for instance, high salt, high pressure, low temperature and oligotrophy, not only adapt to survival of actinomycetes but also enhance molecular diversity of actinomycete secondary metabolites production, thus making marine actinomycetes important sources of marine‐based bioactive compounds, especially polyketides. Herein, we summarized the structures and pharmacological activities of polyketides from actinobacteria associated with marine organisms from 2013 to 2019; moreover, the main source species of actinomycetes were discussed as well. We expected that this review would be helpful for future in‐depth research and development of marine‐based bioactive polyketides.