Polymethylated Phloroglucinol Meroterpenoids from  Rhodomyrtus tomentosa  and Their Antibacterial and Acetylcholinesterase Inhibitory Effects | Zendy

Liu Hui | Zendy; Li Ping | Zendy; Bi LiSha | Zendy; Wu WenJuan | Zendy; Yan Huan | Zendy; He Li | Zendy; Qin XuJie | Zendy; Liu HaiYang | Zendy

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Polymethylated Phloroglucinol Meroterpenoids from Rhodomyrtus tomentosa and Their Antibacterial and Acetylcholinesterase Inhibitory Effects

Author(s) -

Liu Hui,

Li Ping,

Bi LiSha,

Wu WenJuan,

Yan Huan,

He Li,

Qin XuJie,

Liu HaiYang

Publication year - 2020

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.202000489

Subject(s) - phloroglucinol , chemistry , acetylcholinesterase , antibacterial activity , aché , inhibitory postsynaptic potential , circular dichroism , stereochemistry , minimum inhibitory concentration , terpene , biochemistry , enzyme , antibiotics , bacteria , organic chemistry , biology , neuroscience , genetics

Rhotomentodiones C−E, three new polymethylated phloroglucinol meroterpenoids with diverse configurations, were isolated from the twigs and leaves of Rhodomyrtus tomentosa . Their structures and absolute configurations were established mainly by means of comprehensive spectroscopic data and electron circular dichroism (ECD) calculation. Among them, Rhotomentodione D ( 2 ) exhibited both antibacterial activity with an MIC value of 12.5 μg/mL against Propionibacterium acnes and AChE inhibitory activity with an IC 50 value of 22.9 μ m .

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