Premium
Polymethylated Phloroglucinol Meroterpenoids from Rhodomyrtus tomentosa and Their Antibacterial and Acetylcholinesterase Inhibitory Effects
Author(s) -
Liu Hui,
Li Ping,
Bi LiSha,
Wu WenJuan,
Yan Huan,
He Li,
Qin XuJie,
Liu HaiYang
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000489
Subject(s) - phloroglucinol , chemistry , acetylcholinesterase , antibacterial activity , aché , inhibitory postsynaptic potential , circular dichroism , stereochemistry , minimum inhibitory concentration , terpene , biochemistry , enzyme , antibiotics , bacteria , organic chemistry , biology , neuroscience , genetics
Rhotomentodiones C−E, three new polymethylated phloroglucinol meroterpenoids with diverse configurations, were isolated from the twigs and leaves of Rhodomyrtus tomentosa . Their structures and absolute configurations were established mainly by means of comprehensive spectroscopic data and electron circular dichroism (ECD) calculation. Among them, Rhotomentodione D ( 2 ) exhibited both antibacterial activity with an MIC value of 12.5 μg/mL against Propionibacterium acnes and AChE inhibitory activity with an IC 50 value of 22.9 μ m .