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Neuraminidase Inhibitors from the Roots of Caragana sinica
Author(s) -
Park SeonJu,
Kim Nanyoung,
Nhiem Nguyen Xuan,
Kwak Hee Jae,
Yang Hyun Wook,
Kim Seung Hyun
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000470
Subject(s) - chemistry , neuraminidase , clostridium perfringens , neuraminic acid , nuclear magnetic resonance spectroscopy , stereochemistry , biochemistry , sialic acid , enzyme , bacteria , biology , genetics
Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α‐viniferin, wistin, and 5‐hydroxy‐2‐[(4‐hydroxyphenyl)acetyl]‐3‐methoxybenzoic acid, were isolated from the roots of Caragana sinica . These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1 H‐NMR spectroscopy, CD spectroscopy, and time‐dependent density‐functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens . Among the tested compounds, 5‐hydroxy‐2‐[(4‐hydroxyphenyl)acetyl]‐3‐methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.