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Lignans, Monoterpenes and γ‐ Pyrone Derivatives from Patrinia scabiosifolia with Cytotoxic Activity against HCT‐116 Cells
Author(s) -
Zhang Xuan,
Rui MengJue,
Xu HongTao,
Chou GuiXin
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000397
Subject(s) - chemistry , pyrone , stereochemistry , circular dichroism , cytotoxicity , cytotoxic t cell , derivative (finance) , absolute configuration , in vitro , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , economics , financial economics
One new dihydrobenzofuran neolignan, patrinianeolignan I, two new monoterpenes, 6,7‐dehydrodissectol A and patriniaol A, and a new γ‐ pyrone derivative, hydroxymaltol 3‐ O ‐(6′‐ O ‐ trans‐ caffeoyl)‐ β ‐D‐glucopyranoside, along with fifteen known lignans, eight known monoterpenes, and two known γ‐ pyrone derivatives, were isolated from the whole plant of Patrinia scabiosifolia . Their structures were elucidated by 1D‐ and 2D‐NMR and HR‐ESI‐MS analysis. The absolute configuration of patrinianeolignan I was confirmed by circular dichroism (CD) spectrum. All compounds were evaluated in vitro for their cytotoxic activity against HCT‐116 cells. The results showed that compounds patriniaol A and eudesmin exhibited moderate cytotoxicity against HCT‐116 cells with IC 50 values of 42.23 μM and 41.92 μM, respectively.