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Naphthalenones and Naphthols Isolated from the Saussurea laniceps Endophytic Fungus Didymella glomerata X223
Author(s) -
Luo Gangyuan,
Chen Senhua,
Yu Jianchen,
Yuan Jie,
Zheng Li,
Liu Lan,
Chen Bin,
Li Jing
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000315
Subject(s) - chemistry , fungus , terpene , stereochemistry , botany , traditional medicine , biology , medicine
One new naphthalenone, didymelol A, and three new naphthols, didymelol B–D, together with three known naphthalenones, (3 S ,4 R )‐3,4,6‐trihydroxy‐3,4‐dihydronaphthalen‐1(2 H )‐one, (4 S )‐4,6‐dihydroxy‐3,4‐dihydronaphthalen‐1(2 H )‐one, (4 S )‐4‐hydroxy‐3,4‐dihydronaphthalen‐1(2 H )‐one, were isolated from the Saussurea laniceps endophytic fungus Didymella glomerata X223. The structures of the isolates were elucidated based on extensive spectroscopic data analysis. The absolute configuration of didymelol A was established through single‐crystal X‐ray diffraction data and didymelols B–D were identified through comparisons of experimental and calculated ECD spectra. All compounds were evaluated for cytotoxic activity against human non‐small cell lung cancer A549 cells and human breast carcinoma MDA‐MB‐435 cells.