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Nitric Oxide Production Inhibitory Eudesmane‐Type Sesquiterpenoids from Artemisia argyi
Author(s) -
Zhang LaiBin,
Nie XiaoNa,
Chang JiaJing,
Wang FengLong,
Lü JieLi
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000238
Subject(s) - nitric oxide , chemistry , sesquiterpene , inhibitory postsynaptic potential , stereochemistry , terpene , terpenoid , lipopolysaccharide , artemisia , quercetin , sesquiterpene lactone , traditional medicine , biochemistry , organic chemistry , biology , medicine , neuroscience , antioxidant , endocrinology
Six new eudesmane‐type sesquiterpene derivatives, artemargyinins A–F were isolated from the leaves of Artemisia argyi . Their structures were elucidated based on the extensive analysis of spectroscopic data. Artemargyinins A–F feature a lactone ring‐opening eudesmane‐type sesquiterpene with an isoprenoid group at C(8). All compounds were tested for their inhibitory effects on lipopolysaccharide‐induced nitric oxide (NO) production in RAW264.7 macrophages. Artemargyinins A–F showed more potent NO production inhibitory activity with IC 50 values ranging from 7.66±0.53 to 61.19±2.54 μM than the positive control quercetin (IC 50 =74.34±1.39 μM). Among them, artemargyinins C and D exhibited strong inhibitory activity with IC 50 values of 8.08±0.21 and 7.66±0.53 μM, respectively.