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Cytotoxic Meroterpenoids from the Fungus Alternaria sp. JJY‐32
Author(s) -
Wang Lu,
Jiao Jieying,
Liu Dan,
Zhang Xiaomin,
Li Jing,
Che Qian,
Zhu Tianjiao,
Zhang Guojian,
Li Dehai
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000226
Subject(s) - chemistry , circular dichroism , fungus , cytotoxicity , alternaria , stereochemistry , cytotoxic t cell , biochemistry , botany , biology , in vitro
Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY‐32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL‐60 and HO8910 cells with IC 50 values of 7.54 and 20.32 μ m .