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New Derivatives from Microbial Transformation of ent ‐Kaur‐16‐en‐19‐oic Acid by Cunninghamella echinulata
Author(s) -
Song Chenggang,
Liu Juan,
Wang Haoyu,
Li Xiang,
Liu Bing,
Zhang Mingzhe,
Shan Xiaohui,
Li He,
Gao Jinming,
Qin Jianchun
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000178
Subject(s) - cytotoxicity , biotransformation , chemistry , fungus , transformation (genetics) , human breast , stereochemistry , cell culture , biochemistry , in vitro , cancer cell , cancer , gene , botany , biology , enzyme , genetics
Biotransformation of ent ‐kaur‐16‐en‐19‐oic acid using fungus Cunninghamella echinulata resulted in two novel hydroxylated metabolites together with five known compounds. Their structures were elucidated by means of extensive NMR and HR‐ESI‐MS data analysis. The eight compounds were measured for their cytotoxicity against the human breast carcinoma (MCF‐7) and human hepatoblastoma (HepG‐2) cell lines. Seven compounds showed no cytotoxicity to the two cell lines. One compound displayed moderate cytotoxicity against HepG‐2 and MCF‐7 with the IC 50 values of 12.6 and 27.1 μM, respectively.