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Antibacterial Mechanism of Curcumin: A Review
Author(s) -
Zheng Dantong,
Huang Chongxing,
Huang Haohe,
Zhao Yuan,
Khan Muhammad Rafi Ullah,
Zhao Hui,
Huang Lijie
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000171
Subject(s) - curcumin , chemistry , phototoxicity , quorum sensing , biofilm , antibacterial activity , bacterial growth , mechanism of action , antimicrobial , polyphenol , microbiology and biotechnology , photosensitizer , bacteria , virulence , biochemistry , antioxidant , in vitro , biology , photochemistry , organic chemistry , genetics , gene
Curcumin is a plant‐derived polyphenolic active substance with broad‐spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of antioxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.