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Chartarlactams Q−T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities
Author(s) -
Liu Dong,
Li Yong,
Guo Xingchen,
Ji Wei,
Lin Wenhan
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000170
Subject(s) - chemistry , staphylococcus aureus , pathogen , stereochemistry , antibacterial activity , fungus , fermentation , virus , bacteria , microbiology and biotechnology , biochemistry , virology , biology , genetics , botany
Four new phenylspirodrimane‐type dimers, namely chartarlactams Q−T, along with stachyin B were isolated from the fermentation broth of a sponge‐derived fungus Stachybotrys chartarum WGC‐25 C‐6. Chartarlactams Q−T were structurally featured by the dimerization of two units of phenylspirodrimane linked by a C−N bond. Their structures were determined on the basis of extensive spectroscopic analysis, while quantum ECD calculation and modified Mosher's method were used for the assignment of absolute configurations. Chartarlactams Q−S and stachyin B showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 μg/mL to 16 μg/mL, and chartarlactam T exhibited significant inhibition toward ZIKV virus.