Premium
Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp
Author(s) -
Zhang XiuMei,
Peng AiHong,
Xie WeiDong,
Wang Mei,
Zheng Dan,
Feng MingKuan
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000140
Subject(s) - chemistry , streptomyces , hexokinase , phenylacetic acid , enzyme , biochemistry , stereochemistry , glucanase , bacteria , biology , glycolysis , genetics
Insect‐microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3‐benzotriazin‐4(1 H )‐one and 4‐(2‐aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4‐(2‐Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC 50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 μM, respectively.