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Caesalpanins A–C, Three Dimeric Cassane Diterpenoids from the Seeds of Caesalpinia sappan L.
Author(s) -
Wang DeSheng,
Nie Wei,
Jiang TingTing,
Ding LinFen,
Song LiuDong,
Wu XingDe,
Zhao QinShi
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000103
Subject(s) - chemistry , terpenoid , dimer , stereochemistry , nitric oxide , cytotoxic t cell , ether , traditional medicine , organic chemistry , biochemistry , in vitro , medicine
Three dimeric cassane diterpenoids, caesalpanins A–C, were isolated from the seeds of Caesalpinia sappan L., as well as three known compounds. Their structures were determined via analysis of 1D‐, 2D‐NMR, and HR‐ESI‐MS data. Caesalpanins A and B were the second and third compounds that presented a nitrogen‐containing cassane diterpenoid dimer linked through one ether bond between C‐19 and C‐20′. Caesalpanin B exhibited moderate cytotoxic activity against MCF‐7 cell lines with IC 50 value of 29.98 μ m . Caesalpanins A and B had weak inhibitory effects against LPS‐induced nitric oxide (NO) production in RAW 264.7 macrophages at 50 μ m with inhibitory rate of 36.01 % and 32.93 %, respectively.