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Aaptolines A and B, Two New Quinoline Alkaloids from the Marine Sponge Aaptos aaptos
Author(s) -
Tang WeiZhuo,
Yu HaoBing,
Lu JingRong,
Lin HouWen,
Sun Fan,
Wang ShuPing,
Yang Fan
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000074
Subject(s) - quinoline , chemistry , sponge , stereochemistry , moiety , cytotoxicity , biochemistry , organic chemistry , in vitro , biology , botany
Two new quinoline alkaloids, aaptolines A and B, were isolated from the marine sponge Aaptos aaptos . Their structures were determined by HR‐ESI‐MS data, NMR analysis, and X‐ray crystallography. Structurally, aaptoline A is characterized as having a quinoline skeleton fused with a 1,4‐dioxane motif at the C(7)−C(8) position, whereas aaptoline B possessed an intriguing 1 H ‐pyrrolo[2,3‐ g ]quinoline moiety. The cytotoxic assay of these compounds showed no cytotoxicity towards HepG2, A549, and PC9 cancer cell lines and had IC 50 values greater than 20 μ m .