Aaptolines A and B, Two New Quinoline Alkaloids from the Marine Sponge  Aaptos aaptos | Zendy

Tang WeiZhuo | Zendy; Yu HaoBing | Zendy; Lu JingRong | Zendy; Lin HouWen | Zendy; Sun Fan | Zendy; Wang ShuPing | Zendy; Yang Fan | Zendy

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Aaptolines A and B, Two New Quinoline Alkaloids from the Marine Sponge Aaptos aaptos

Author(s) -

Tang WeiZhuo,

Yu HaoBing,

Lu JingRong,

Lin HouWen,

Sun Fan,

Wang ShuPing,

Yang Fan

Publication year - 2020

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.202000074

Subject(s) - quinoline , chemistry , sponge , stereochemistry , moiety , cytotoxicity , biochemistry , organic chemistry , in vitro , biology , botany

Two new quinoline alkaloids, aaptolines A and B, were isolated from the marine sponge Aaptos aaptos . Their structures were determined by HR‐ESI‐MS data, NMR analysis, and X‐ray crystallography. Structurally, aaptoline A is characterized as having a quinoline skeleton fused with a 1,4‐dioxane motif at the C(7)−C(8) position, whereas aaptoline B possessed an intriguing 1 H ‐pyrrolo[2,3‐ g ]quinoline moiety. The cytotoxic assay of these compounds showed no cytotoxicity towards HepG2, A549, and PC9 cancer cell lines and had IC 50 values greater than 20 μ m .

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