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Lignans and Terpenoids from the Leaves of Schisandra chinensis
Author(s) -
Liu GuoZhen,
Liu Yan,
Sun YanPing,
Li XiaoMao,
Xu ZhenPeng,
Jiang Peng,
Rong XiaoHui,
Yang BingYou,
Kuang HaiXue
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.202000035
Subject(s) - lignan , terpenoid , schisandra chinensis , chemistry , cytotoxicity , schisandra , cancer cell lines , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , traditional medicine , in vitro , cancer cell , biochemistry , cancer , biology , medicine , alternative medicine , pathology , traditional chinese medicine , genetics
Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC‐803, Caco‐2 and Ishikawa cell lines. Some compounds showed strong cytotoxicity against these three cancer cell lines with IC 50 <1 μ m .