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Ansavaricin J, a New Heterocyclic Ring‐Fused Streptovaricin from Gene stvP5‐Deleted Mutant of Streptomyces spectabilis CCTCC M2017417
Author(s) -
Liu YuanZhen,
Chen Xu,
Li ZhengYuan,
Huang Li–Xia,
Sun YuHui
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900713
Subject(s) - ring (chemistry) , chemistry , mutant , stereochemistry , streptomyces , staphylococcus aureus , antibacterial activity , gene , genetics , bacteria , biology , biochemistry , organic chemistry
A new ring‐fused streptovaricin analogue, named ansavaricin J, was unprecedently isolated from the culture of the genetically modified strains ΔstvP5 which derived from Streptomyces spectabilis CCTCC M2017417. Its structure was elucidated via comprehensive spectroscopic analyses, including 1D‐ and 2D‐NMR tests, and HR‐ESI‐MS data analysis. Notably, ansavaricin J and E represent the only two reported examples of heterocyclic ring‐fused streptovaricins thus far, however, it only showed insignificant antibacterial activities against Staphylococcus aureus .