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A New Alkaloid from the Aerial Parts of Bupleurum chinense DC.
Author(s) -
Xiao ZongYu,
Liu Yan,
Sun YanPing,
Liu Yuan,
Yang BingYou,
Kuang HaiXue
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900697
Subject(s) - alkaloid , bupleurum , chemistry , hela , mtt assay , traditional medicine , stereochemistry , botany , biochemistry , biology , cell , medicine , alternative medicine , pathology , traditional chinese medicine
A new isoalloxazine alkaloid, named bupleurine A ( 1 ), along with five known compounds ( 2 – 6 ), were isolated from the aerial parts of Bupleurum chinense DC. The structure elucidation of the new alkaloid ( 1 ) was employed by combining NMR and HR‐MS data with comparison of reference in the literature. Five known compounds ( 2 – 6 ) were isolated from Bupleurum genus for the first time. Additionally, their antiproliferative activities on HeLa cells were evaluated by MTT assay and IC 50 of compounds 1 and 4 – 6 were below 10 μ m after treatment for 24 h.