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Cytotoxic Activity of Cunila angustifolia Essential Oil
Author(s) -
Sousa Matheus H. O.,
Morgan Jessica M. S.,
Cesca Karina,
Flach Adriana,
Moura Neusa F.
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900656
Subject(s) - menthone , pulegone , chemistry , essential oil , ic50 , cytotoxic t cell , cell culture , selectivity , chromatography , stereochemistry , biochemistry , in vitro , biology , genetics , catalysis
The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC‐FID and GC‐MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF‐7) and skin melanoma (SK‐Mel‐28). The assay showed the highest selectivity, to MCF‐7 cell lines, with IC 50 equal to 34.0 μg mL −1 , low selectivity for SK‐Mel‐28 cell lines, with IC 50 equal to 279.9 μg mL −1 , and no mortality to A549 cell lines.