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Antibacterial Diphenyl Ether, Benzophenone and Xanthone Derivatives from Aspergillus flavipes
Author(s) -
Ji YuBin,
Chen WenJu,
Shan TiZhuang,
Sun BiYun,
Yan PengCheng,
Jiang Wei
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900640
Subject(s) - chemistry , benzophenone , bacteria , diphenyl ether , antibacterial activity , xanthone , vibrio parahaemolyticus , ether , bioassay , positive control , microbiology and biotechnology , stereochemistry , organic chemistry , traditional medicine , biology , genetics , medicine
The extract of the strain Aspergillus flavipes DL‐11 exerted antibacterial activities against six Gram‐positive bacteria. During the following bioassay‐guided separation, ten diphenyl ethers ( 1 – 10 ), two benzophenones ( 11 – 12 ), together with two xanthones ( 13 – 14 ) were isolated. Among them, 4′‐chloroasterric acid ( 1 ) was a new chlorinated diphenyl ether. Their structures were elucidated by extensive spectroscopic data analysis, including IR, HR‐ESI‐MS, NMR experiments, and by comparison with the literature data. All compounds showed moderate to strong antibacterial effects on different Gram‐positive bacteria with MIC values that ranged from 3.13 to 50 μg/mL, but none of the compounds exhibited activity against Gram‐negative bacteria Vibrio parahaemolyticus ATCC17802 (MIC>100 μg/mL). In particular, the MICs of some compounds are at the level of positive control.