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Quinoline Based Monocarbonyl Curcumin Analogs as Potential Antifungal and Antioxidant Agents: Synthesis, Bioevaluation and Molecular Docking Study
Author(s) -
Nagargoje Amol A.,
Akolkar Satish V.,
Siddiqui Madiha M.,
Subhedar Dnyaneshwar D.,
Sangshetti Jaiprakash N.,
Khedkar Vijay M.,
Shingate Bapurao B.
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900624
Subject(s) - chemistry , cryptococcus neoformans , curcumin , docking (animal) , miconazole , antioxidant , aspergillus flavus , candida albicans , stereochemistry , biochemistry , antifungal , microbiology and biotechnology , biology , food science , medicine , nursing
In search for new fungicidal and free radical scavenging agents, we synthesized a focused library of 2‐chloroquinoline based monocarbonyl analogs of curcumin (MACs). The synthesized MACs were evaluated for in vitro antifungal and antioxidant activity. The antifungal activity was evaluated against five different fungal strains such as Candida albicans , Fusarium oxysporum , Aspergillus flavus , Aspergillus niger , and Cryptococcus neoformans , respectively. Most of the synthesized MACs displayed promising antifungal activity compared to the standard drug Miconazole. Furthermore, molecular docking study on a crucial fungal enzyme sterol 14 α ‐demethylase (CYP51) could provide insight into the plausible mechanism of antifungal activity. MACs were also screened for in vitro radical scavenging activity using butylated hydroxytoluene (BHT) as a standard. Almost all MACs exhibited better antioxidant activity compared to BHT.