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New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13
Author(s) -
Zhou Zhenbin,
Wu Qiaoling,
Xie Qing,
Ling Chunyao,
Zhang Hua,
Sun Changli,
Ju Jianhua
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900560
Subject(s) - chemistry , streptomyces , stereochemistry , cytotoxic t cell , bacteria , biochemistry , biology , genetics , in vitro
Borrelidins M−O ( 1 – 3 ), along with four previously known family members ( 4 – 7 ), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1 – 3 were elucidated by extensive spectral analyses of HR‐ESI‐MS, 1D and 2D NMR data. In addition, the cytotoxic and antibacterial activities of 1 – 7 were evaluated enabling us to propose some tentative structure‐activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7) and C(8) of the borrelidin scaffold.