Premium
Synthesis of New Lathyrane Diterpenoid Derivatives from Euphorbia lathyris and Evaluation of Their Anti‐Inflammatory Activities
Author(s) -
Wang Wang,
Wu Yanli,
Li Chen,
Yang Yueying,
Li Xingzhou,
Li Hua,
Chen Lixia
Publication year - 2020
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.201900531
Subject(s) - euphorbia , chemistry , cytotoxicity , terpenoid , euphorbiaceae , anti inflammatory , derivative (finance) , in vitro , stereochemistry , biochemistry , traditional medicine , pharmacology , botany , biology , medicine , economics , financial economics
Abstract Euphorbia factor L 3 , a lathyrane diterpenoid extracted from Euphorbia lathyris , was found to display good anti‐inflammatory activity with very low cytotoxicity. To find more potent anti‐inflammatory drugs, two series of Euphorbia factor L 3 derivatives with fatty and aromatic acids were designed and synthesized. Among them, lathyrane derivative 5n exhibited most potent inhibition on LPS‐induced NO production in RAW264.7 cells with no obvious cytotoxicity. To determine the key characteristics of Euphorbia factor L 3 derivatives that contribute to anti‐inflammatory activity, we conducted a structure‐activity relationship study of these compounds.